I worked on a project with Hapi a few years ago where we built out a huge REST API, and it was _really_ nice. Once we had our basic scaffolding set up, implementing new endpoints with request/response validation, error handling, etc, was really quick. It's got a really nice ecosystem of tools around it but they're all pluggable so by default you don't get the kitchen sink.
Definitely worth a look if you've never strayed far from Express...