It depends on what the focus is. I might recommend a jQuery base for a web based application that didn't serve to mostly display content today, outside of that VueJS is about as easy to graft on, similar for preact/inferno as other JSX/React look alikes at a relatively low overhead.
My preference for applications is for React first. Vue just doesn't feel like it would scale to full-size Applications. Both vue and angular seem to have holes in their server-rendering options and angular in particular seems far more complicated than putting the lego pieces together with react + mobx/redux and fetch/axios.
There are a few jquery alternatives if you want to inherit most of the utility bits without the bulk.