Same, I have been using Zod heavily for the past year.
Hono looks really cool, but I got too comfortable with NestJS to make the jump :D
I should really give it a try though
I'd say it (Hono) is about half a step above Oak or Koa in that it's a similar pattern with a "standard" entry that works pretty well cross-environment... Native for Deno and Cloudflare (I think Bun too) and a small shim for Node.js, the only hard-ish part is there's some inconsistency between publishing of different parts between npm and jspm, also some of the environment specific modules were a bit more difficult to work out (at least in deno) as a result.
I've toyed with CF Workers/Pages deployments with Turso and D1... I want to like the CF hosting stuff, but have a few times had issues where I'm actively developing and the test environment deployments bork.
I haven't used Next/Nest enough to fairly comment on them. I'm not really a fan of page based routing, not to mention for apps, I don't really care about SEO, so have been fine with SPA React.